On the Week 15 NFL schedule, we have the Rams (+2.5) as the best against-the-spread bet on the card. Keep reading for more tips on point spreads and totals, including parlay possibilities.

NFL Picks Against the Spread – Week 15

Jump to Matchup:

Pick: Rams +2.5 vs. 49ers

• Matchup: Los Angeles Rams at San Francisco 49ers
• Projected Winner & Margin: 49ers by 1.8 points (Bet on this game at BetMGM)
• Spread: 49ers -2.5
• Time: 8:15 p.m. ET
• Date: Dec. 12
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Cowboys +2.5 vs. Panthers

• Matchup: Dallas Cowboys at Carolina Panthers
• Projected Winner & Margin: Cowboys by 1.7 points (Bet on this game at BetMGM)
• Spread: Panthers -2.5
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Lions -2.5 vs. Bills

• Matchup: Buffalo Bills at Detroit Lions
• Projected Winner & Margin: Lions by 8.6 points (Bet on this game at BetMGM)
• Spread: Lions -2.5
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Texans -3 vs. Dolphins

• Matchup: Miami Dolphins at Houston Texans
• Projected Winner & Margin: Texans by 10.5 points (Bet on this game at BetMGM)
• Spread: Texans -3
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +3 vs. Chargers

• Matchup: Tampa Bay Buccaneers at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 0.7 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks +3 vs. Packers

• Matchup: Green Bay Packers at Seattle Seahawks
• Projected Winner & Margin: Packers by 2.9 points (Bet on this game at BetMGM)
• Spread: Packers -3
• Time: 8:20 p.m. ET
• Date: Dec. 15
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jaguars +3.5 vs. Jets

• Matchup: New York Jets at Jacksonville Jaguars
• Projected Winner & Margin: Jaguars by 1.4 points (Bet on this game at BetMGM)
• Spread: Jets -3.5
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs -4 vs. Browns

• Matchup: Kansas City Chiefs at Cleveland Browns
• Projected Winner & Margin: Chiefs by 13.3 points (Bet on this game at BetMGM)
• Spread: Chiefs -4
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -4 vs. Colts

• Matchup: Indianapolis Colts at Denver Broncos
• Projected Winner & Margin: Broncos by 7.9 points (Bet on this game at BetMGM)
• Spread: Broncos -4
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Titans +5 vs. Bengals

• Matchup: Cincinnati Bengals at Tennessee Titans
• Projected Winner & Margin: Bengals by 2.4 points (Bet on this game at BetMGM)
• Spread: Bengals -5
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -5 vs. Steelers

• Matchup: Pittsburgh Steelers at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 8.2 points (Bet on this game at BetMGM)
• Spread: Eagles -5
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Raiders +5 vs. Falcons

• Matchup: Atlanta Falcons at Las Vegas Raiders
• Projected Winner & Margin: Falcons by 3.1 points (Bet on this game at BetMGM)
• Spread: Falcons -5
• Time: 8:30 p.m. ET
• Date: Dec. 16
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals -5.5 vs. Patriots

• Matchup: New England Patriots at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 15.8 points (Bet on this game at BetMGM)
• Spread: Cardinals -5.5
• Time: 4:25 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +7 vs. Commanders

• Matchup: Washington Commanders at New Orleans Saints
• Projected Winner & Margin: Commanders by 4.5 points (Bet on this game at BetMGM)
• Spread: Commanders -7
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings -7 vs. Bears

• Matchup: Chicago Bears at Minnesota Vikings
• Projected Winner & Margin: Vikings by 17.4 points (Bet on this game at BetMGM)
• Spread: Vikings -7
• Time: 8 p.m. ET
• Date: Dec. 16
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +15 vs. Ravens

• Matchup: Baltimore Ravens at New York Giants
• Projected Winner & Margin: Ravens by 13.9 points (Bet on this game at BetMGM)
• Spread: Ravens -15
• Time: 1 p.m. ET
• Date: Dec. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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